PIH1 The Clinical Consequences of Exposure to Clinically Important Drug-Drug Interactions

Clinically important drug interactions.

Ability of pharmacy clinical decision-support software to alert users about clinically important drug-drug interactions

OBJECTIVE Pharmacy clinical decision-support (CDS) software that contains drug-drug interaction (DDI) information may augment pharmacists' ability to detect clinically significant interactions. However, studies indicate these systems may miss some important interactions. The purpose of this study was to assess the performance of pharmacy CDS programs to detect clinically important DDIs. DESIG...

Pharmacist workload and pharmacy characteristics associated with the dispensing of potentially clinically important drug-drug interactions.

BACKGROUND Drug-drug interactions (DDIs) are preventable medical errors, yet exposure to DDIs continues despite systems that are designed to prevent such exposures. The purpose of this study was to examine pharmacy characteristics that may be associated with dispensed potential DDIs. METHODS This study combined survey data from community pharmacies in 18 metropolitan statistical areas with ph...

Molecular basis of cardiovascular drug metabolism: implications for predicting clinically important drug interactions.

The recent withdrawal of the calcium antagonist mibefradil from the market in the United States has refocused attention on drug interactions that involve cardiovascular drugs.1 It is appropriate to ask whether pharmacokinetic drug interactions like this that pose substantial clinical risk can be predicted and/or prevented. We believe that if the appropriate information is obtained during drug d...

Clinically relevant drug interactions with antiepileptic drugs.

Some patients with difficult-to-treat epilepsy benefit from combination therapy with two or more antiepileptic drugs (AEDs). Additionally, virtually all epilepsy patients will receive, at some time in their lives, other medications for the management of associated conditions. In these situations, clinically important drug interactions may occur. Carbamazepine, phenytoin, phenobarbital and primi...